What is PDRN?

PDRN (Polydeoxyribonucleotide) is a DNA fragment that helps the skin heal, regenerate, and produce collagen. It’s usually sourced from salmon sperm and used in medical and cosmetic treatments.

What are the sources of PDRN?

PDRN can be extracted from different parts of fish or produced synthetically. Each source affects DNA quality, biological activity, and clinical performance.

1. Wild salmon sperm
   The most trusted and clinically validated source.
   Highest Quality—Gold Standard.

• Purity: Very high (≥98%)
• DNA Length: Long, intact chains (800–1200 kDa)
• Clinical Performance: Excellent — most studied, strongest regeneration and repair
• Use: premium injectables and advanced skin boosters
  Preferred by top manufacturers and clinics.

2. Farmed salmon sperm
   A widely used source, though quality can vary depending on farming conditions.
   Good Quality—But Variable.

• Purity: Moderate to high (85–95%)
• DNA Length: Medium to long (600–900 kDa)
• Clinical Performance: Effective, but less consistent than wild
• Use: Mid-range injectables, some topical applications
  Depends on fish health and farming practices.

3. Salmon meat or organs (testes, liver, muscle)
   An accessible source but with technical limitations.
   Moderate Quality—Requires Extra Purification.

• Purity: Variable (70–90%)
• DNA Length: Shorter chains (300–600 kDa)
• Clinical Performance: Weaker; less stable; requires more filtration
• Use: Lower-cost injectables or cosmetic-use products
  Less commonly used in regulated medical applications.

4. Trout
   A cost-effective source with limited clinical validation.
   Low Quality—Budget Alternative.

• Purity: Variable (60–85%)
• DNA Length: Short (300–500 kDa)
• Clinical Performance: Minimal data; inconsistent outcomes
• Use: Some cosmetic or research use
  Rare in professional-grade formulas.

5. Synthetic PDRN
   Created in laboratories for specific formulations.
   High Purity—But Limited Natural Activity.

• Purity: Very high (98–100%)
• DNA Length: Short and uniform (50–300 kDa)
• Clinical Performance: Safe and stable, but lacks full biological complexity
• Use: Topical serums, allergen-free products, research-grade use
  Not commonly used in injectables due to its reduced regenerative effect.

Why is wild salmon sperm the best source for PDRN?

Not all PDRN is created equal. Clinical studies consistently show that wild salmon sperm provides the highest-quality DNA for regenerative treatments.

• It contains long, intact DNA chains (800–1200 kDa), which are more biologically active.
• It offers superior purity (≥98%) with minimal contamination from proteins or enzymes.
• It is clinically validated in both medical and aesthetic fields.
• It delivers more consistent and measurable results compared to farmed or synthetic alternatives.

That’s why Rivolab chooses only wild salmon sperm-derived PDRN for all our formulations.

How does Rivolab select pharmaceutical-grade PDRN?

At Rivolab, we specialize in formulating advanced skincare—not manufacturing raw DNA extracts ourselves. That’s why we carefully select our PDRN from trusted pharmaceutical partners who meet the highest global standards.

We only work with suppliers who offer:

• Wild salmon origin, with full traceability
• GMP and ISO 13485 certifications to ensure pharmaceutical compliance
• Purity ≥98%, confirmed via HPLC and endotoxin testing
• Controlled molecular weight, optimized for both injectables and topicals
• Consistent DNA chain length, safety, and biological activity

Only after meeting these stringent criteria do we incorporate the PDRN into our formulations—ensuring results that are clinically supported, safe, and effective.

How do you ensure PDRN quality and safety?

Every batch of PDRN used by Rivolab undergoes strict evaluation before entering production.
Our quality assurance process includes:

• Supplier audit and documentation review
• COA verification for purity, DNA profile, and endotoxins
• Compatibility testing with our delivery systems (injectable or topical)
• In-house QC checks before and after formulation
• Full batch traceability and regulatory documentation available on request

This ensures that our products meet medical-grade standards and deliver reliable performance with every application.